Availability and access to biological human samples is crucial for the progress of biomedical research. COMET, our collection of human metabolic tissues, provides the scientific community with samples of high quality in order to allow the identification and validation of new molecular factors associated with the onset of type 2 diabetes.
Clinical protocol
The collection includes tissues of interest for carbohydrate metabolism, which will be collected during bariatric surgery performed on obese patients (BMI > 35). Three different patient groups, corresponding to different stages of the disease, will be constituted:
Insulin sensitive
Insulin resistant
Type 2 diabetes
The collection will include a great number of patients and a wide variety of tissues involved in metabolic dysfunction, as well as blood derived products:
Muscle
Liver
Sub-cutaneous and visceral fat
Epiploic artery
Plasma & Serum
Genomic DNA
The available phenotypic data, associated to the samples, include:
Clinical data
- onset of obesity
- onset of diabetes
- comorbidities
- concomitant therapies
- family history
Biological analyses
- serologies
- fasting blood glucose
- fasting plasma insulin
- HBA1c
- total cholesterol and HDL
- triglycerides
- uric acid
- ASAT
- ALAT
- γGT
- PAL
- bilirubine
- CRP
- C Peptide
- FFA
- complete blood cell count
- creatine
A long-term follow-up of the patients undergoing bariatric surgery will allow us to collect plasma and serum not only immediately before surgery but also 3 and 12 months after.
Technology transfer
For the R&D services of companies, as well as for academic teams, the COMET Biobank offers a potential of substantial discoveries directly transferable to human clinic:
- Understanding of pathophysiological mechanisms involved in type 2 diabetes;
- Research of novel therapeutic targets
- Research of diagnostic markers to follow the progression of type 2 diabetes
- Evaluation of effectiveness of pharmacological treatments
- Better stratification of patients for the choice of antidiabetic therapies
Context
Diabetes is one of the most widespead diseases in the world. About 382 million patients are concerned, making diabetes a major public health issue. Over 90% of diabetic persons have type 2 diabetes.
people have diabetes
have type 2 diabetes
Quality control
Sample quality management is paramount for research excellence. The COMET collection of human metabolic tissues follows a quality process to guarantee that all steps from sample preparation to storage are normalized by standard operating procedures, controlled by validation steps and recorded on sample life sheets.
Teams
BC2M : Bio-communication in cardio-metabolism
University Montpellier
Pr Anne Lajoix
Professor
University Montpellier
Dr Sandra Rebuffat
PhD, Project leader
Agathe Nouvel
Research engineer
Jonas Laget
Research engineer
Centre of Bbiological Rresources Montpellier Hospital
Pr David Nocca
Surgeon, Collection Scientific Supervisor
Dr Nadège Padilla-Renaud
Coordinator clinical trial
Dr Florence Galtier
Principal Investigator, Diabetologist - Technician
Philippe Géraud
Clinical Research Assistant
Dr Nicolas Builles
Collection Operational Manager
Dr Guilhem Couderc
Tissu Bank Manager
Partnerships
Contacts
SATT AxLR
950 rue Saint-Priest, CSU - Bât. 6 - 34090 Montpellier - France
Centre of Biological Resources
Montpellier Hospital
Hôpital Saint-Éloi, 80 avenue Augustin Fliche - 34090 Montpellier - France